产品货号：
Z37636
中文名称：
FTO抗体
英文名称：
Anti-FTO Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-FTO Antibody |
| 指标别名 | FTO;KIAA1752 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | FTO |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human FTO Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation.Has highest activity towards single-stranded RNA containing 3-methyluracil,followed by single-stranded DNA containing 3-methylthymine. |
| 计算分子量 | 58KD |
| 实际分子量 | 58KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Alpha-ketoglutarate-dependent dioxygenase FTO,also known as Fat mass and obesity-associated protein,FTO and KIAA1752,is a nucleus protein which belongs to the fto family.FTO is ubiquitously expressed,with relatively high expression in adrenal glands and brain;especially in hypothalamus and pituitary.FTO is a dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation.FTOhas highest activity towards single-stranded RNA containing 3-methyluracil,followed by single-stranded DNA containing 3-methylthymine.It has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine.FTO has no activity towards 1-methylguanine.It has no detectable activity towards double-stranded DNA.FTO requires molecular oxygen,alpha-ketoglutarate and iron.FTO contributes to the regulation of the global metabolic rate,energy expenditure andenergy homeostasis.It contributes to the regulation of body size and body fat accumulation as well.Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death.The disease consists of a severe children multiple congenital anomaly syndrome with death by the age of 3 years.All affected individuals had postnatal growth retardation,microcephaly,severe psychomotor delay,functional brain deficits,and characteristic facial dysmorphism. |
| Uniprot ID | Q9C0B1 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | Alpha-ketoglutarate-dependent dioxygenase FTO |
| 蛋白名全称 | Alpha-ketoglutarate-dependent dioxygenase FTO |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
相关搜索：FTO抗体，FTO单抗，Anti-FTO Antibody